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Published on: November 21, 2013
Prevalence and patient characteristics associated with CIN 3 in adolescents
Aine E Clements1, Christina A Raker, Amy S Cooper
1Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island and the Alpert Medical School of Brown University, Providence, RI, USA.
Objective:
We sought to identify patient characteristics associated with cervical intraepithelial neoplasia (CIN) 3 in adolescents.
Study Design:
A cross-sectional cohort study was done using a colposcopic database. Data collected included demographic and clinical information as well as cytologic and histologic results. Variables associated with CIN 3 in the univariable analysis (P ≤ .10) were included in a multivariable logistic regression model.
Results:
Of 614 adolescents evaluated, 48 (8%; 95% confidence interval, 6-10%) had CIN 3. No cancers were detected. In the univariable analysis, parity, ≥ 4 lifetime male sexual partners, and a history of sexually transmitted infections were associated with an increased risk of CIN 3. In the final model, only ≥ 4 sexual partners (compared to <4; adjusted odds ratio, 3.66; 95% confidence interval, 1.26-10.61) was significantly associated with the finding of CIN 3.
Conclusion:
CIN 3 was infrequently encountered in adolescents, and those with multiple sexual partners were at increased risk for CIN 3.
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