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[Immunological alterations and selectin values in hypertensive patients treated according to current criteria]

Raquel Cortés1, Manuel Portolés, Esther Roselló-Lletí

  • 1Unidad de Cardiocirculación, Centro de Investigación, Hospital Universitario La Fe, Valencia, España.

Medicina Clinica
|December 15, 2010
PubMed

Insights

Essential hypertension is linked to increased E-selectin and P-selectin levels, indicating immunological activation. Left ventricular hypertrophy (LVH) did not significantly alter these selectin concentrations in patients.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Hypertension Studies

Background:

  • Essential hypertension is a prevalent cardiovascular condition.
  • Immunological factors are increasingly recognized in hypertension pathogenesis.
  • Selectins play a role in inflammatory processes.

Purpose of the Study:

  • To investigate the relationship between E-selectin and P-selectin levels and immunological changes in essential hypertension.
  • To assess the influence of left ventricular hypertrophy (LVH) on these markers.

Main Methods:

  • Quantified selectins (E and P) and cytokines in 261 essential hypertension patients.
  • Included patients with and without left ventricular hypertrophy (LVH).
  • Utilized multivariate analysis to identify independent factors.

Main Results:

  • Elevated E-selectin and P-selectin levels were observed in hypertensive patients compared to controls.
  • Significant correlations were found between selectin levels and immunological markers.
  • Interleukin-1 receptor antagonist (IL-1ra) and P-selectin were independent predictors of E-selectin levels.

Conclusions:

  • Immunological activation significantly influences selectin concentrations in asymptomatic essential hypertension patients.
  • Left ventricular hypertrophy (LVH) did not demonstrate a significant impact on selectin levels.
Abstract

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