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[Atorvastatin and oxidized low density lipoprotein antibody. Relationship to age]

Juan Francisco Sánchez Muñoz-Torrero1, Leandro Crespo, Luis Fernández Pereira

  • 1Unidad de Riesgo Vascular de Medicina Interna, Hospital San Pedro de Alcántara, Cáceres, España. jfsmt@unex.es

Medicina Clinica
|December 15, 2010
PubMed

Insights

Plasma LDLoxab levels in hypercholesterolemic patients correlate with age, waist circumference, and C-reactive protein. Atorvastatin treatment did not alter LDLoxab levels, but changes were linked to age.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Hypercholesterolemia is a significant risk factor for cardiovascular disease.
  • Oxidized LDL (LDLoxab) is implicated in atherogenesis.
  • Understanding LDLoxab dynamics in response to statin therapy is crucial.

Purpose of the Study:

  • To investigate the relationship between plasma LDLoxab levels and cardiovascular variables in hypercholesterolemic patients.
  • To assess the impact of atorvastatin treatment on LDLoxab levels.
  • To explore correlations between LDLoxab changes and patient characteristics.

Main Methods:

  • A study involving 48 hypercholesterolemic patients.
  • Measurement of LDLoxab, lipid profiles, oxidative stress, and inflammatory biomarkers at baseline and after 24 weeks of atorvastatin (20mg).
  • Statistical analysis to determine correlations and treatment effects.

Main Results:

  • Baseline LDLoxab positively correlated with age, waist circumference, and C-reactive protein.
  • Atorvastatin treatment did not significantly change plasma LDLoxab levels.
  • The percentage change in LDLoxab at 24 weeks was negatively correlated with age.

Conclusions:

  • Plasma LDLoxab levels are associated with age, waist circumference, and C-reactive protein in hypercholesterolemic individuals.
  • Atorvastatin therapy does not alter LDLoxab levels.
  • Age may influence the immunomodulatory effects of LDLoxab variations during statin treatment.
Abstract

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