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Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom
Angel Moldes-Anaya1, Thomas Rundberget, Silvio Uhlig
1Section of Chemistry and Toxicology, National Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway. angel.moldes-anaya@vetinst.no
Abstract:
Chemical investigation of three isolates of Penicillium crustosum Thom cultures, one of which was derived from a recent dog poisoning investigation, has led to the isolation and structure elucidation of secopenitrem D (1). Penitrems A-F and roquefortine C were also present in the isolates analyzed. The structure of 1 was unambiguously assigned based on extensive 1D and 2D-NMR spectroscopic experiments, MS-aided structural studies and by comparison with structurally related congeners. Secopenitrem D lacks the C-16-C-18 ether linkage present in penitrems A-F.

