Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.

Nature genetics·2026
Same author

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.

bioRxiv : the preprint server for biology·2026
Same author

Microenvironmentally derived fatty acid-binding proteins 4 and 5 are novel therapeutic vulnerabilities in multiple myeloma.

Blood neoplasia·2026
Same author

Chromatin Engagement and Transcriptional Activity of the ZNF217 Exon 4-Skipping Isoform Are Associated with Breast Cancer Aggressiveness and Bone Metastasis.

Cancers·2026
Same author

Targeting NOTCH3 to eradicate dormant and therapy-resistant multiple myeloma cells.

Journal of experimental & clinical cancer research : CR·2026
Same author

Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism.

Experimental hematology·2025

Related Experiment Video

Updated: Jun 6, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
06:00

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

Bisphosphonates in preclinical bone oncology.

Philippe Clézardin1, Ismahène Benzaïd, Peter I Croucher

  • 1INSERM, UMR, IFR, Lyon, France. philippe.clezardin@inserm.fr

Bone
|December 15, 2010
PubMed
Summary

Nitrogen-containing bisphosphonates inhibit bone destruction in cancer patients. Preclinical studies show these drugs also possess anticancer effects, inhibiting tumor growth and enhancing chemotherapy efficacy.

Area of Science:

  • Oncology
  • Pharmacology
  • Bone Biology

Background:

  • Bisphosphonates, particularly nitrogen-containing ones, are standard treatments for bone metastases.
  • They effectively inhibit osteoclast activity, preventing bone resorption.
  • Emerging evidence suggests broader therapeutic potential beyond bone protection.

Purpose of the Study:

  • To review preclinical evidence on the anticancer activities of nitrogen-containing bisphosphonates.
  • To explore their direct and indirect mechanisms against cancer.
  • To provide insights into ongoing research in animal models.

Main Methods:

  • Review of preclinical studies and animal models of cancer.
  • Analysis of data on tumor cell function, angiogenesis, and immune response.

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
06:00

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

Published on: September 13, 2017

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

  • Examination of effects on chemotherapy potentiation.

    • Main Results:

    • Nitrogen-containing bisphosphonates demonstrate direct inhibition of tumor cell proliferation and migration.
    • These agents enhance the efficacy of chemotherapy drugs.
    • Evidence supports their role in inhibiting tumor angiogenesis and stimulating anti-tumor immunity.

    Conclusions:

    • Nitrogen-containing bisphosphonates exhibit significant anticancer properties.
    • Their multifaceted actions suggest potential as adjunct cancer therapies.
    • Further preclinical research is warranted to explore their full therapeutic capacity.