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Development of a rapid LC-MS/MS method for ribavirin determination in rat brain
Elisa Zironi1, Teresa Gazzotti, Barbara Lugoboni
1Department of Veterinary Public Health and Animal Pathology, Alma Mater Studiorum, University of Bologna, via Tolara di Sopra 50, Ozzano dell'Emilia, Bologna, Italy.
Abstract:
A rapid and specific liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of ribavirin (RBV) in rat brain was developed. Sample preparation required only two centrifuge steps before LC-MS/MS analysis and the chromatographic separation was achieved in isocratic conditions using an Atlantis T3 column with a nearly totally aqueous (95%) mobile phase. The method showed a good linearity over a concentration range of 5-1000ppb and satisfactory results in terms of accuracy.
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