Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interferon-gamma-inducible protein-10 is associated to increased primary bile acids and fibrosis in primary sclerosing cholangitis.

The Journal of steroid biochemistry and molecular biology·2026
Same author

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average-Risk Populations, and Future Directions.

International journal of cancer·2026
Same author

Longitudinal Surveillance of Gastric Polyposis in Familial Adenomatous Polyposis: Incidence, Progression, and Endoscopic Outcomes.

United European gastroenterology journal·2026
Same author

Recommendations on Drug Selection and Dose Adjustment for Patients with Liver Cirrhosis: Results from a Multidisciplinary Expert Panel.

Clinical drug investigation·2026
Same author

Therapeutic plasma exchange in amatoxin associated acute liver failure-results from the multi-center Amanita-PEX study.

Critical care (London, England)·2025
Same author

Real-World Molecular Testing in European Early-Onset Colorectal Cancer.

United European gastroenterology journal·2025
Same journal

Retraction notice to "Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population" [J Hepatol 58 (2013) 271-277].

Journal of hepatology·2026
Same journal

Optimising the screening strategy for early-stage hepatocellular carcinoma.

Journal of hepatology·2026
Same journal

Corrigendum to: "A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse" [J Hepatol (2014) 60: 782-91].

Journal of hepatology·2026
Same journal

Declining but persistent hepatocellular cancer risk beyond 10 years of entecavir or tenofovir in chronic hepatitis B: Results of the PAGE-B cohort.

Journal of hepatology·2026
Same journal

Ivonescimab plus gemcitabine and cisplatin as first-line therapy for advanced biliary tract cancer: a multicenter, open-label phase 2 trial.

Journal of hepatology·2026
Same journal

Durvalumab with gemcitabine-based chemotherapy regimens in advanced biliary tract cancer: primary results from the phase IIIb TOURMALINE study.

Journal of hepatology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Interferon-lambda serum levels in hepatitis C.

Bettina Langhans1, Bernd Kupfer, Ingrid Braunschweiger

  • 1Department of Internal Medicine I, University of Bonn, Bonn, Germany. bettina.langhans@ukb.uni-bonn.de

Journal of Hepatology
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) infection impairs dendritic cell function. Higher interferon-lambda (IFN-λ) levels correlate with spontaneous HCV resolution, suggesting a key role for IFN-λ in controlling the infection.

More Related Videos

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
06:28

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

Related Experiment Videos

Last Updated: Jun 6, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
06:28

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

Area of Science:

  • Immunology
  • Virology
  • Hepatology

Background:

  • Dendritic cells (DCs) are crucial for adaptive immunity and antiviral cytokine production.
  • Hepatitis C virus (HCV) infection significantly impairs DC function.
  • Previous research focused on type I and II interferons (IFNs), but the role of IFN-lambdas in HCV was less understood.

Purpose of the Study:

  • To investigate serum levels of IFN-lambda1 (IL-29) and IFN-lambda2/3 (IL-28A/B) in patients with varying HCV infection outcomes.
  • To explore the association between IFN-lambda levels, the rs12979860 T/C polymorphism, and HCV infection status.
  • To determine if HCV proteins directly affect IFN-lambda production.

Main Methods:

  • Serum samples were analyzed using ELISAs to quantify IL-29 and IL-28A/B levels.
  • Results were stratified based on the rs12979860 T/C polymorphism near the IL-28B gene.
  • In vitro experiments assessed the impact of HCV proteins (NS3, E2) on IL-29 production in stimulated DCs.

Main Results:

  • IL-29 serum levels were generally twofold higher than IL-28A/B.
  • Both IL-29 and IL-28A/B levels were significantly higher in carriers of the rs12979860 C allele compared to TT homozygotes.
  • IL-29 levels were markedly lower in chronic HCV patients than in healthy controls or those with resolved infection.
  • HCV proteins NS3 and E2 directly inhibited IL-29 production in DCs.
  • Higher IL-29 levels were observed in patients who spontaneously resolved HCV compared to those who developed chronic infection.

Conclusions:

  • HCV proteins can directly inhibit IFN-lambda production in DCs.
  • The rs12979860 C allele, associated with HCV resolution, correlates with increased IFN-lambda levels.
  • Elevated IFN-lambda levels appear to promote spontaneous resolution of HCV infection.
  • IFN-lambdas play a significant role in controlling Hepatitis C virus infection.