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Related Experiment Video

Updated: Jun 6, 2026

Using a Classroom-Based Deese Roediger McDermott Paradigm to Assess the Effects of Imagery on False Memories

Using a Classroom-Based Deese Roediger McDermott Paradigm to Assess the Effects of Imagery on False Memories

Published on: November 14, 2018

Presidential address: imagination trumps knowledge.

Frederick A Moore¹

¹Division of Surgical Critical Care and Acute Care Surgery, Department of Surgery, The Methodist Hospital, Houston, TX, USA. famoore@tmhs.org

American Journal of Surgery

|December 15, 2010

Summary

This summary is machine-generated.

Multiple organ failure (MOF) involves distinct inflammatory trajectories, with the gut influencing both early and late stages. Understanding gut dysfunction is key to managing MOF and sepsis.

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Area of Science:

Immunology
Gastroenterology
Critical Care Medicine

Background:

Multiple organ failure (MOF) research has evolved over 30 years, focusing on multidisciplinary translational approaches.
MOF exhibits a bimodal trajectory, with the gut implicated in both early and late phases.

Discussion:

Early MOF is linked to excessive systemic inflammatory response syndrome (SIRS), amplified by gut ischemia-reperfusion.
Late MOF involves compensatory anti-inflammatory response syndrome (CARS) and progressive gut dysfunction, leading to sepsis.

Key Insights:

The gut acts as a critical immunologic organ influencing MOF progression.
Gut dysfunction serves as a reservoir for pathogens and toxins, exacerbating CARS and causing late sepsis.

Outlook:

Further research into gut-targeted therapies may improve outcomes for patients with MOF.
Translational research integrating gut-focused strategies is essential for advancing MOF understanding and treatment.