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Updated: Jun 6, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Conscious sedation for upper digestive endoscopy performed by endoscopists
Ana Laura Colle Kauling1, Giovani de Figueiredo Locks, Guilherme Muriano Brunharo
1Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil. laurinhakauling@yahoo.com.br
Conscious sedation for upper digestive endoscopy frequently causes hypoxia and hypotension, especially in obese patients. Monitoring vital signs is crucial during these procedures.
Area of Science:
- Gastroenterology
- Anesthesiology
- Critical Care Medicine
Background:
- Conscious sedation is widely used for ambulatory procedures like upper digestive endoscopy.
- Despite its common use, conscious sedation carries inherent risks.
- This study evaluates hemodynamic and oxygenation parameters during endoscopic sedation.
Purpose of the Study:
- To assess blood pressure, heart rate, and oxygen saturation in patients undergoing upper digestive endoscopy under conscious sedation.
- To identify potential risks and patient factors influencing outcomes.
Main Methods:
- 105 adult patients (ASA I-III) undergoing upper digestive endoscopy were included.
- Sedation was induced using midazolam or meperidine.
- Noninvasive monitoring of blood pressure, pulse oximetry, and heart rate was performed throughout the procedure.
Main Results:
- While overall vital sign variations were not statistically significant, significant incidences of hypoxia (41.9%), hypotension (53.3%), and tachycardia (25.6%) were observed.
- Obese patients showed a higher susceptibility to hypoxia and hypotension compared to non-obese individuals.
Conclusions:
- The combined use of midazolam and meperidine for conscious sedation in upper digestive endoscopy is associated with a high incidence of hypoxia and hypotension.
- Obesity is identified as a risk factor for hypoxemia and arterial hypotension in this setting.
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