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Updated: Jun 6, 2026

Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
Ig-related renal disease in lymphoplasmacytic disorders: an update
Pierre Ronco1, Emmanuelle Plaisier, Pierre Aucouturier
1Assistance Publique - Hôpitaux de Paris, Hôpital Tenon, Service de Néphrologie et Dialyses, Paris, France. pierreronco@yahoo.fr
Abstract:
Ig-related renal diseases occurring in lymphoplasmacytic disorders (LPD) cover a wide spectrum of renal lesions. Except for cast nephropathy, which is almost specific for multiple myeloma, similar renal lesions caused by deposition or precipitation of monoclonal Ig-related material may occur in the various types of LPD. Because the secreted Ig provides the link between the LPD and the kidney disease, the renal outcome is linked to efficacy of chemotherapy. In the past 10 years, considerable advances have occurred in chemotherapy regimens with the advent of new classes of drugs, which already result in markedly improved renal and vital survival.
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