Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
Introduction to Virus01:28

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
What are Viruses?00:50

What are Viruses?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A functional map of phosphoprotein phosphatase regulation identifies an evolutionarily conserved reductase for the catalytic metal ions.

Nature communications·2026
Same author

Systematic discovery of motif-based interactions of the auxiliary domains of USP family deubiquitinases.

Nature communications·2026
Same author

Uncovering cancer dependencies in peptide-interacting protein pockets.

bioRxiv : the preprint server for biology·2026
Same author

Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders.

The FEBS journal·2026
Same author

A proteome-wide dependency map of protein interaction motifs.

Nature structural & molecular biology·2026
Same author

Corrigendum to "E6 Proteins from Diverse Papillomaviruses Self-Associate Both In Vitro and In Vivo" [J. Mol. Biol. 396(1) (2010) 90-104].

Journal of molecular biology·2026
Same journal

Drugging the proteome via large-scale chemoproteomics.

Trends in biochemical sciences·2026
Same journal

Peptideins: Navigating the gray zone of the proteome.

Trends in biochemical sciences·2026
Same journal

A metabolon channels nicotine biosynthesis.

Trends in biochemical sciences·2026
Same journal

Better call chaperone.

Trends in biochemical sciences·2026
Same journal

Biochemistry at scale: Seeing both the forest and the trees.

Trends in biochemical sciences·2026
Same journal

Voices across Asia and Oceania: Biochemistry across borders.

Trends in biochemical sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

How viruses hijack cell regulation.

Norman E Davey1, Gilles Travé, Toby J Gibson

  • 1Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. davey@embl.de

Trends in Biochemical Sciences
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Viruses hijack host proteins to replicate, using short linear motifs (SLiMs) to mimic cellular functions. This genomic strategy allows compact viral genomes to control complex host pathways effectively.

More Related Videos

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Related Experiment Videos

Last Updated: Jun 6, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

Area of Science:

  • Virology
  • Molecular Biology
  • Host-Pathogen Interactions

Background:

  • Viruses are obligate intracellular parasites with intimate host relationships.
  • Viral life cycles depend on interactions with host cellular proteins.
  • Viral genomes are compact, posing a challenge for controlling host processes.

Purpose of the Study:

  • To investigate how viruses manipulate host proteomes despite genomic constraints.
  • To explore the mechanisms viruses use to commandeer diverse cellular pathways.

Main Methods:

  • Analysis of viral-host proteome interactions.
  • Investigation of viral genomic strategies.
  • Focus on molecular mimicry mechanisms.

Main Results:

  • Viruses extensively interact with host proteomes.
  • A key viral strategy involves mimicking host protein short linear motifs (SLiMs).
  • SLiM mimicry allows viruses to exploit host machinery.

Conclusions:

  • Short linear motif mimicry is a crucial mechanism for viral manipulation of host cells.
  • This strategy enables compact viral genomes to control complex host pathways.
  • Understanding SLiM mimicry is key to deciphering viral pathogenesis.