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Updated: Jun 6, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins
Daisuke Nakamura1, Akio Tsuru, Kentaro Ikegami
1Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.
Abstract:
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress. The ER stress sensor inositol requiring enzyme-1beta (IRE1β), which is specifically expressed in intestinal epithelial cells, is thought to be involved in translational repression. However, its mechanism of action is not fully understood. Using a reporter that can evaluate and distinguish between translation efficiency in the cytosol and on the ER membrane, we show here that IRE1β represses translation on the ER membrane but not in the cytosol, and that this selective repression depends on the RNase activity of IRE1β.
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