Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphological assessment of visual dysfunction.

R Heywood1, C Gopinath

  • 1Huntington Research Centre, Ltd., Cabridgeshire, United Kingdom.

Toxicologic Pathology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial.

Medical law review·2022
Same author

Samter's triad with aural involvement: a novel approach to management.

The Journal of laryngology and otology·2014
Same author

Prospective, comparative, cohort study comparing the rhinogram, Sino-Nasal Outcome Test-20 and Heath-Related Quality of Life questionnaire.

The Journal of laryngology and otology·2010
Same author

Spontaneously occurring extra-islet endocrine cell proliferation in the pancreas of young Beagle dogs.

Toxicology letters·2010
Same author

A case of brachial amyotrophy mimicking rupture of the flexor digitorum profundus tendon.

The Journal of hand surgery, European volume·2008
Same author

Following anterior resection for rectal cancer, defunctioning ileostomy closure may be significantly delayed by adjuvant chemotherapy: a retrospective study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2007
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026
Same journal

Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue.

Toxicologic pathology·2026
Same journal

Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice.

Toxicologic pathology·2026
See all related articles

The eye is highly sensitive to toxins, with varied reactions due to its unique biology. Ocular toxicity mechanisms remain poorly understood, and animal models like albino rats may not accurately predict human responses.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Pharmacology

Background:

  • The eye possesses unique anatomical, physiological, and biochemical features, contributing to its high sensitivity to toxic substances.
  • Diverse reactions to ocular injury highlight the eye's specialized nature.

Purpose of the Study:

  • To explore the complexities of ocular toxicity and its prediction.
  • To evaluate the suitability of animal models for ocular toxicity studies.
  • To understand the mechanisms underlying ocular toxicity.

Main Methods:

  • Review of existing literature on ocular toxicity.
  • Analysis of species-specific responses to toxic compounds.
  • Evaluation of predictive models for ocular toxicity in humans.

Related Experiment Videos

Main Results:

  • The albino rat is unsuitable for retinal toxicity studies due to phototoxicity and spontaneous pathologies.
  • Ocular toxicity cannot be reliably predicted from chemical structure alone.
  • Pharmacological side effects in animals are often predictive of human responses.

Conclusions:

  • Understanding ocular toxicity requires considering the eye's unique biological characteristics.
  • Species-specific data and careful model selection are crucial for assessing ocular risks.
  • Further research is needed to elucidate the mechanisms of ocular toxicity.