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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
Is carotid artery disease responsible for perioperative strokes after coronary artery bypass surgery?
Yuebing Li1, John Castaldo, Jan Van der Heyden
1Division of Neurology, Lehigh Valley Health Network, Allentown, PA 18103, USA.
Insights
Simultaneous carotid endarterectomy and coronary artery bypass surgery may be safe but evidence for necessity is debated. Further clarification is needed to justify combined procedures for patients with both coronary and carotid disease.
Area of Science:
- Vascular Surgery
- Neurology
- Cardiology
Background:
- Coronary and extracranial carotid arteries are frequently affected by atherosclerotic disease.
- Stroke is a significant complication of coronary artery surgery.
- Simultaneous revascularization of both vascular beds is reported but necessity is debated.
Purpose of the Study:
- To clarify the evidence justifying simultaneous carotid endarterectomy and coronary artery bypass surgery.
- To evaluate the necessity of combined procedures in patients with comorbid coronary and carotid disease.
Main Methods:
- Review of existing vascular surgery literature.
- Analysis of evidence regarding perioperative stroke causes.
- Discussion of treatment outcomes in patients with dual vascular disease.
Main Results:
- Simultaneous coronary and carotid revascularization is generally reported as safe.
- Evidence supporting the necessity of combined procedures remains circumstantial.
- Multiple stroke etiologies exist in coronary bypass patients, complicating outcome analysis.
Conclusions:
- The necessity of simultaneous carotid endarterectomy and coronary artery bypass surgery requires further investigation.
- Distinguishing stroke causes in patients with both coronary and carotid disease is challenging.
- More evidence is needed to definitively justify combined surgical approaches.
Abstract:
The coronary and extracranial carotid vascular beds are often simultaneously affected by significant atherosclerotic disease, and stroke is one of the potential major complications of coronary artery surgery. As a result, there is no shortage of reports in the vascular surgery literature describing simultaneous coronary and carotid artery revascularizations. Generally, these reports have found this combination of operations safe, but have stopped short of proving that it is necessary. Intuitively, simultaneous carotid endarterectomy and coronary artery bypass surgery could be justified if most perioperative strokes were the result of a significant carotid stenosis, either directly or indirectly. At first glance this appears to be a fairly straightforward issue; however, much of the evidence on both sides of the argument is circumstantial. One significant problem in analyzing outcome by choice of treatment in patients presenting with both coronary and carotid disease is the multiple potential causes of stroke in coronary bypass patients, which include hemorrhage and atheroemboli from aortic atheromas during clamping. But this controversial subject is now open to discussion, and our debaters have been given the challenge to clarify the evidence to justify their claims.
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