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Published on: January 16, 2019
Factors associated with a prolonged QT interval in liver cirrhosis patients
Ioana Mozos1, Camelia Costea, Corina Serban
1Department of Pathophysiology, University of Medicine and Pharmacy "Victor Babes," Timisoara, Romania. ioanamozos@yahoo.de
Aim:
The aim of this study was to identify factors associated with prolonged QT interval in liver cirrhosis patients.
Materials And Methods:
Thirty-eight patients with liver cirrhosis were enrolled in this study. The maximal QT interval (QTmax), heart rate-corrected QT interval (QTc), QT interval in lead DII (QTII), and mean QT interval (QTm) were determined manually, using 12-lead electrocardiogram. Additional laboratory tests were also performed.
Results:
The following values were obtained: QTmax, 435 ± 43 milliseconds; QTc, 493 ± 46 milliseconds; QT interval in lead DII, 405 ± 46 milliseconds; and mean QT interval, 400 ± 40 milliseconds. Ten (6%) patients had a prolonged QTmax, and 27 (71%) had a prolonged QTc. The highest values were obtained for QTc and QTmax in patients with alcoholic cirrhosis and Child-Pugh class C, respectively. A moderate correlation was observed between QTmax and serum uric acid (URCA; r = 0.504), and multiple linear regression analysis revealed that URCA was significantly associated with QTc and heart rate.
Conclusions:
Liver disease severity, alcoholic etiology, and URCA are associated with prolonged QT interval in patients with liver cirrhosis.
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