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Related Experiment Video

Updated: Jun 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

dGlucose is linked to renal function changes in diabetes.

Anil K Mandal¹, Linda M Hiebert, Harry Khamis

¹Department of Medicine, University of Florida, Gainesville, FL, USA. amandal@med-spec.com

Diabetes Research and Clinical Practice

|December 15, 2010

Summary

This summary is machine-generated.

The change in glucose (dglucose) from fasting to two hours postprandial better predicts kidney function changes in diabetics than fasting glucose alone. Controlling postprandial hyperglycemia is vital for renal protection.

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Assessment of Kidney Function in Mouse Models of Glomerular Disease

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Published on: June 30, 2018

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Last Updated: Jun 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Area of Science:

Nephrology
Endocrinology
Diabetology

Background:

Diabetes mellitus is a leading cause of chronic kidney disease.
Accurate prediction of glycemic control is essential for managing diabetic complications.
Fasting glucose and two-hour postprandial glucose are common glycemic markers.

Purpose of the Study:

To evaluate if the change in glucose (dglucose) from fasting to two-hour postprandial predicts glycemic control and renal function better than fasting glucose (F) or two-hour postprandial glucose (2 hPPglucose).

Main Methods:

Collected fasting glucose, 2-hour postprandial glucose, and renal function variables (BUN, serum creatinine, eGFR) from 56 insulin-treated diabetic adults.
Calculated the change in glucose (dglucose = 2 hPPglucose - F).
Compared variables between groups with 2 hPPglucose <200 mg/dL and >200 mg/dL, and calculated correlation coefficients.

Main Results:

Significant differences were observed between F and 2 hPPglucose for most variables.
The change in serum creatinine (dScr) was significant when comparing the two postprandial glucose groups (p=0.0327).
dglucose significantly correlated with dScr (r=0.420) and estimated GFR (deGFR) (r=-0.434) in all patients, and particularly in those with 2 hPPglucose >200 mg/dL.

Conclusions:

The change in glucose (dglucose) is a superior predictor of renal function changes compared to fasting glucose or 2-hour postprandial glucose alone.
Effective control of postprandial hyperglycemia, especially when levels exceed 200 mg/dL, is critical for preserving kidney function in diabetic patients.