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Angiotensin II receptors and drug discovery in cardiovascular disease

Chiranjib Dasgupta1, Lubo Zhang

  • 1Fetal-Origin Diseases Institute, First Affiliated Hospital of Soochow University, Suzhou 215000, China.

Drug Discovery Today
|December 15, 2010
PubMed

Insights

Hypertension and cardiovascular diseases are linked to Angiotensin II (Ang II) receptors. Genetic factors influencing these receptors can increase cardiovascular risk and hypertension, particularly during fetal development.

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Genetics

Background:

  • Hypertension is a major cardiovascular disease.
  • High blood pressure can lead to cardiovascular remodeling and endothelial dysfunction.
  • Angiotensin II (Ang II) receptors are key players in hypertension.

Purpose of the Study:

  • To review the expression and function of Ang II receptors.
  • To explore the role of Ang II receptors in programming cardiovascular diseases in utero.
  • To discuss therapeutic interventions targeting Ang II stimulation.

Main Methods:

  • Literature review focusing on Ang II receptor expression and function.
  • Analysis of genetic and epigenetic factors influencing Ang II receptors.
  • Examination of in utero programming of cardiovascular diseases.

Main Results:

  • Certain Ang II receptor variants are linked to increased cardiovascular risk and hypertension.
  • Ang II receptors play a significant role in cardiovascular disease development.
  • In utero exposure and genetic factors can program long-term cardiovascular health.

Conclusions:

  • Understanding Ang II receptor mechanisms is crucial for cardiovascular disease prevention.
  • Targeting Ang II receptors offers potential therapeutic strategies.
  • Early-life interventions may mitigate hypertension and cardiovascular risks.

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