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Oculomotor nerve paralysis induced by alpha II-interferon
Acta Neurologica Belgica
|January 1, 1990
Summary
Alpha II-interferon caused bilateral oculomotor nerve paralysis in a hairy-cell leukemia patient. Symptoms resolved after discontinuing the drug, highlighting potential neurological side effects.
Area of Science:
- Neuro-oncology
- Pharmacology
- Hematology
Background:
- Hairy-cell leukemia is a rare B-cell malignancy.
- Alpha II-interferon is a cytokine used in treating certain cancers.
- Neurological side effects of alpha II-interferon are known but uncommon.
Observation:
- A patient with hairy-cell leukemia developed bilateral oculomotor nerve paralysis.
- The paralysis occurred during treatment with alpha II-interferon.
- Neurological deficits resolved completely after cessation of alpha II-interferon therapy.
Findings:
- Alpha II-interferon can induce oculomotor nerve palsy.
- This case suggests a direct neurotoxic effect of alpha II-interferon.
- Review of literature indicates frequent neurological, psychiatric, and EEG abnormalities with alpha II-interferon.
Implications:
- Clinicians should be vigilant for neurological complications during alpha II-interferon therapy.
- Oculomotor nerve paralysis is a potential adverse effect of alpha II-interferon.
- Early recognition and drug withdrawal can reverse interferon-induced neurotoxicity.