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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
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Therapy response evaluation with positron emission tomography-computed tomography.

George M Segall1

  • 1Nuclear Medicine Service, VA Palo Alto Health Care System, Palo Alto, CA, USA. george.segall@va.gov

Seminars in Ultrasound, CT, and MR
|December 15, 2010
PubMed
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F-18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) shows promise for assessing solid tumor treatment response. However, standardized protocols and response criteria are needed for wider clinical trial adoption and consistent interpretation.

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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Published on: June 7, 2024

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) is utilized for evaluating therapy response in solid tumors.
  • Its adoption in clinical trials is limited by protocol variability and lack of universal response criteria.

Purpose of the Study:

  • To discuss the challenges and potential of FDG PET-CT in assessing treatment response in solid tumors.
  • To explore the utility of semiquantitative methods and descriptive terminology in clinical practice versus clinical trials.

Main Methods:

  • Review of current practices and proposed criteria for FDG PET-CT response assessment.
  • Discussion of semiquantitative metrics like standard uptake value (SUV) for tissue glucose metabolism.
  • Analysis of the applicability of clinical trial response terms (e.g., partial response, complete response, progressive disease) in clinical practice.

Main Results:

  • Gestalt impression can be accurate for identifying progressive disease and complete response in individual patients.
  • Semiquantitative methods, such as SUV, can describe glucose metabolism and therapeutic changes if quality control is maintained.
  • Clinical trial response terms have specific meanings and definitions that are difficult to apply in routine clinical practice.

Conclusions:

  • Standardized acquisition and processing protocols, along with universal response criteria, are crucial for broader FDG PET-CT adoption in clinical trials.
  • In clinical practice, descriptive terminology agreed upon by imaging physicians and clinicians may be more practical than strict clinical trial criteria.
  • Careful quality control is essential for the reliable use of semiquantitative FDG PET-CT data in assessing treatment response.