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Pediatric Neurologic Complications Associated With Influenza A H1N1

Yuval E Landau1, Galia Grisaru-Soen, Shimon Reif

  • 1Pediatric Neurology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. yuval.landau@childrens.harvard.edu

Pediatric Neurology
|December 15, 2010
PubMed

Insights

Influenza A H1N1 infection in children can cause neurologic complications, most commonly seizures. While generally mild, these neurological effects warrant consideration during diagnosis.

Area of Science:

  • Pediatrics
  • Neurology
  • Infectious Diseases

Background:

  • Influenza is linked to various neurological complications.
  • Limited data exists on neurological complications specifically from influenza A H1N1.
  • This study focuses on pediatric cases of influenza A H1N1 with neurological involvement.

Purpose of the Study:

  • To describe the neurological complications in children hospitalized with influenza A H1N1.
  • To review the demographics and clinical characteristics of these neurological presentations.

Main Methods:

  • Retrospective study of hospitalized children with laboratory-confirmed influenza A H1N1 and neurological complications.
  • Data collected over a 4-month winter period.
  • Review of patient demographics and clinical features of neurological presentations.

Main Results:

  • 19% (14/74) of hospitalized children with influenza A H1N1 had neurological complications.
  • Seizures (febrile and nonfebrile) were the most common complication (71%).
  • Other complications included transverse myelitis, myositis, expressive aphasia, and syncope; most cases were mild.

Conclusions:

  • Neurological complications of influenza A H1N1 in children are often mild, with seizures being most frequent.
  • Influenza A H1N1 should be considered in the differential diagnosis of pediatric neurological conditions during outbreaks.
  • Prompt recognition is crucial for appropriate management and to prevent potential sequelae.

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