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Related Experiment Video

Updated: Jun 6, 2026

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

Do patients with schizophrenia benefit from a self-referential memory bias?

Philippe-Olivier Harvey¹, Junghee Lee, William P Horan

¹Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles 90073-1003, United States. poharvey@ucla.edu

Schizophrenia Research

|December 15, 2010

Summary

Patients with schizophrenia do not show the memory benefits for self-referenced information that healthy individuals do. This impaired self-referential memory may contribute to social deficits in schizophrenia.

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Area of Science:

Neuroscience
Cognitive Psychology
Psychiatry

Background:

Self-referential processing, linking internal/external stimuli to the self, is crucial for social cognition but understudied in schizophrenia.
Healthy individuals exhibit enhanced memory for self-referenced stimuli compared to other semantic processing.
The impact of self-referential processing on memory in schizophrenia remains largely unknown.

Purpose of the Study:

To investigate whether schizophrenia patients exhibit a memory enhancement for self-referenced information.
To compare self-referential memory performance in schizophrenia patients versus healthy controls.

Main Methods:

A self-referential recognition memory paradigm was employed with 25 schizophrenia patients and 22 healthy controls.
Participants encoded personality adjectives under structural, social desirability, or self-referential (describes me?) conditions.
Recognition memory was assessed using an unexpected yes-no recognition test.

Main Results:

Schizophrenia patients and controls showed comparable memory performance for structural and social desirability conditions.
Patients with schizophrenia exhibited significantly reduced recognition sensitivity for self-referenced adjectives compared to controls (p=0.03).

Conclusions:

Schizophrenia patients lack the memory benefit for self-referenced information observed in healthy individuals.
Impaired self-referential memory in schizophrenia may be linked to medial prefrontal cortex dysfunction.
This memory deficit could partly explain the social functioning difficulties experienced by schizophrenia patients.