Related Experiment Video
Updated: Jun 6, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
[Role of exhaled nitric oxide in predicting steroid response in chronic obstructive pulmonary disease]
1Országos Korányi Tbc és Pulmonológiai Intézet Kórélettani Osztály Budapest Pihenő út 1. 1529. antusb@hotmail.com
Abstract:
Exhaled nitric oxide is the most extensively studied exhaled biomarker. In patients with stable chronic obstructive pulmonary disease exhaled nitric oxide level appears to be normal or only slightly elevated. As exhaled nitric oxide is a good surrogate marker for eosinophilic airway inflammation and eosinophilic inflammation is steroid responsive, patients with elevated exhaled nitric oxide levels may benefit more from a short course of inhaled or systemic corticosteroid treatment. In acute exacerbation most studies report elevated exhaled nitric oxide levels that decrease along with treatment. More importantly, exhaled nitric oxide levels at exacerbation correlate with functional improvements after treatment suggesting the possibility of a role for exhaled nitric oxide in predicting the response to treatment. In conclusion, assessment of airway inflammation using exhaled nitric oxide may identify a subgroup of patients with chronic obstructive pulmonary disease that is likely to benefit from corticosteroid treatment.
Related Concept Videos
COPD: Management Using Bronchodilators and Corticosteroids
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

