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MAO inhibitors: risks, benefits, and lore.

Molly Wimbiscus1, Olga Kostenko, Donald Malone

  • 1Department of Psychiatry and Psychology, P57, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. wimbism@ccf.org

Cleveland Clinic Journal of Medicine
|December 15, 2010
PubMed
Summary

Monoamine oxidase (MAO) inhibitors, once primary antidepressants, are seeing renewed interest. This review covers their clinical use, risks, and benefits, despite past limitations.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Neuroscience

Background:

  • Monoamine oxidase (MAO) inhibitors were the first class of antidepressants developed.
  • Their clinical use declined due to side effects, drug-food interactions, and newer antidepressant classes.
  • Recent interest in MAO inhibitors is growing.

Purpose of the Study:

  • To review the current use of MAO inhibitors in clinical medicine.
  • To discuss the risks associated with MAO inhibitor therapy.
  • To highlight the benefits of MAO inhibitors in treating depression.

Main Methods:

  • Literature review of MAO inhibitor pharmacology and clinical trials.
  • Analysis of safety profiles, including drug and food interactions.
  • Evaluation of efficacy data for various depressive conditions.

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Main Results:

  • MAO inhibitors remain effective antidepressants, particularly for treatment-resistant depression.
  • Careful patient selection and monitoring can mitigate risks.
  • Benefits include broad efficacy and potential for unique mechanisms of action.

Conclusions:

  • MAO inhibitors represent a valuable therapeutic option when used judiciously.
  • Understanding their risks and benefits is crucial for effective clinical application.
  • Revived interest underscores their enduring role in psychiatric pharmacotherapy.