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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

Updated: Jun 6, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Registries in systemic sclerosis: a worldwide experience.

Felice Galluccio1, Ulrich A Walker, Svetlana Nihtyanova

  • 1Department of Biomedicine, Division of Rheumatology AOUC, Denothe Centre, University of Florence, Villa Monna Tessa, viale Pieraccini 18, 50139 Firenze, Italy.

Rheumatology (Oxford, England)
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Scleroderma (SSc) disease registries are crucial for tracking patient data and improving management strategies. These valuable resources enhance disease knowledge and support research for better patient outcomes.

Related Experiment Videos

Last Updated: Jun 6, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Clinical Research
  • Health Informatics

Background:

  • Scleroderma (SSc) is a severe multisystem disease with high mortality and limited treatment options.
  • The increasing complexity and burden of SSc necessitate novel therapeutic and management strategies.
  • Disease registries are essential tools for chronic disease management, capturing vital patient information.

Purpose of the Study:

  • To highlight the importance of SSc registries in research and patient care.
  • To underscore the role of data collection in advancing SSc knowledge.
  • To emphasize the need for ongoing research and data dissemination.

Main Methods:

  • Review of existing national and international SSc registries.
  • Description of data collection and analysis within these registries.
  • Highlighting the EUSTAR MEDS Online registry as a significant international effort.

Main Results:

  • Multiple national SSc registries exist globally (UK, Germany, USA, Canada, Brazil, Australia).
  • The EUSTAR MEDS Online registry collects data from over 8000 patients across 92 centers worldwide.
  • Registries facilitate the collection, analysis, and dissemination of critical patient data.

Conclusions:

  • SSc surveys, research associations, and consortiums are pivotal for advancing disease knowledge.
  • Registries improve understanding of disease progression and treatment responses.
  • Data from registries keep medical professionals updated on SSc management advances.