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Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Lineage Commitment01:21

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Commitment is the  process whereby stem cells:
Cardiomyopathy I: Introduction and Classification01:25

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis I: Introduction01:21

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: Jun 6, 2026

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence
06:27

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

Myocardial lineage development.

Sylvia M Evans1, Deborah Yelon, Frank L Conlon

  • 1Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla CA 92093, USA. syevans@ucsd.edu

Circulation Research
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

This study reviews heart development, focusing on how specialized myocardial lineages form and mature. More research is needed on the maturation of these cardiac cell types for adult heart function.

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Related Experiment Videos

Last Updated: Jun 6, 2026

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence
06:27

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Published on: April 17, 2019

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
10:56

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Published on: March 26, 2015

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
07:30

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Molecular Cardiology

Background:

  • The heart comprises specialized myocardial lineages: ventricular, atrial, and conduction system.
  • Heart development involves ordered lineage specification and maturation through signaling pathways and transcriptional networks.

Purpose of the Study:

  • To summarize and compare knowledge on myocardial lineage specification and maturation across vertebrate models.
  • To highlight knowledge gaps, particularly in factors promoting maturation for adult heart function.

Main Methods:

  • Review and synthesis of existing research on heart development.
  • Comparative analysis of studies from various vertebrate model systems.

Main Results:

  • Significant progress has been made in understanding early myocardial lineage specification.
  • Less is known about the factors driving the subsequent maturation of these lineages.

Conclusions:

  • Understanding myocardial lineage development is crucial for cardiac research.
  • Further investigation into maturation processes is essential for building a functional adult heart.