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Updated: Jun 6, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Improved predictions by Pcons.net using multiple templates
Per Larsson1, Marcin J Skwark, Björn Wallner
1Center for Biomembrane Research, Department of Biochemistry and Biophysics, Swedish e-Science Research Centre, Stockholm Bioinformatics Centre, SciLifeLab, Stockholm University SE-10691 Stockholm, Sweden.
Unlabelled:
Multiple templates can often be used to build more accurate homology models than models built from a single template. Here we introduce PconsM, an automated protocol that uses multiple templates to build protein models. PconsM has been among the top-performing methods in the recent CASP experiments and consistently perform better than the single template models used in Pcons.net. In particular for the easier targets with many alternative templates with a high degree of sequence identity, quality is readily improved with a few percentages over the highest ranked model built on a single template. PconsM is available as an additional pipeline within the Pcons.net protein structure prediction server.
Availability And Implementation:
PconsM is freely available from http://pcons.net/.
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