Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revealing the Hidden Tube: A Simple Laser Solution in a Complex Eye.

Ophthalmology. Glaucoma·2026
Same author

Rho-kinase inhibitors predisposing to secondary keratitis.

BMJ case reports·2026
Same author

Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome: Correlation between Clinical Features, Imaging, and Treatment Response.

Ocular oncology and pathology·2026
Same author

Long-term Clinical Outcomes of Type 1 Keratoprosthesis: A 10-Year Experience.

Cornea·2026
Same author

Early-Onset Normal-Tension Glaucoma in Patients Under 40 Years of Age: Risk Factors for Progression.

Cureus·2026
Same author

<i>ASPH-</i>related ectopia lentis revisited: genetic variability, clinical diversity, and evolving therapeutic approaches.

Ophthalmic genetics·2026
Same journal

Eye injury rates and community cost savings through vision centers: Evidence from southern India.

Indian journal of ophthalmology·2026
Same journal

Evaluation of the protective efficiency of polycarbonate goggles against firecracker-related ocular injuries.

Indian journal of ophthalmology·2026
Same journal

Comment on: Clinical characteristics, risk factor analysis, and outcomes of graft rejection after Descemet membrane endothelial keratoplasty.

Indian journal of ophthalmology·2026
Same journal

Issue regarding E Log book for PG students: Paper to pixels.

Indian journal of ophthalmology·2026
Same journal

Methylation matters: A case control study on epigenetic alteration in diabetic retinopathy.

Indian journal of ophthalmology·2026
Same journal

Understanding the disconnect: A pilot study of public perception versus reality of corneal donation in India.

Indian journal of ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Evidence-based approach to glaucoma management.

Chandrasekhar Garudadri1, Sirisha Senthil, Harsha Laxmana Rao

  • 1VST Center for Glaucoma, LV Prasad Eye Institute, Kallam Anji Reddy Campus, LV Prasad Marg, Road No 2, Banjara Hills, Hyderabad 500 034, Andhra Pradesh, India. gcs@lvpei.org

Indian Journal of Ophthalmology
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Evidence-based medicine requires critical evaluation of new diagnostic and therapeutic methods. Integrating clinical experience and patient views with evidence ensures optimal patient care.

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Related Experiment Videos

Last Updated: Jun 6, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Clinical Research Methodology
  • Healthcare Quality Improvement

Background:

  • Evidence-based medicine (EBM) is a critical framework for modern healthcare.
  • Rapid advancements in diagnostics and therapeutics necessitate rigorous validation.
  • Current practices require a systematic approach to integrating new medical knowledge.

Purpose of the Study:

  • To discuss the core concepts in evaluating diagnostic tests.
  • To outline methods for validating therapeutic interventions.
  • To emphasize the integration of multiple factors for optimal clinical care.

Main Methods:

  • Conceptual review of evidence-based medicine principles.
  • Discussion of evaluation methodologies for diagnostic accuracy.
  • Exploration of study designs for therapeutic efficacy assessment.

Main Results:

  • Critical appraisal is essential before adopting new medical technologies.
  • Evaluation frameworks exist for both diagnostic and therapeutic research.
  • Evidence alone is insufficient for high-quality patient care.

Conclusions:

  • Effective implementation of evidence-based medicine requires robust evaluation techniques.
  • Integrating clinical expertise and patient preferences alongside external evidence is crucial.
  • A holistic approach enhances the delivery of superior healthcare outcomes.