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An Indian perspective on primary angle closure and glaucoma
1Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. rjsihota@hotmail.com
Insights
Primary angle closure disease is common in India, affecting nearly half of adult glaucoma cases. Management involves iridotomy and intraocular pressure control for effective treatment.
Area of Science:
- Ophthalmology
- Glaucoma Research
Background:
- Primary angle closure disease (PACD) is a significant cause of adult primary glaucoma in India.
- Anatomical factors like reduced corneal diameter and anterior chamber depth are noted in PACD patients.
Purpose of the Study:
- To summarize primary angle closure disease in India.
- To review Indian studies on primary angle closure disease.
Main Methods:
- Review of existing Indian studies on primary angle closure disease.
- Analysis of anatomical factors, management strategies, and disease progression.
Main Results:
- Primary angle closure glaucoma constitutes nearly 50% of adult primary glaucomas in Indian hospitals.
- Iridotomy controlled intraocular pressure in 66.7% of subacute and 12.9% of acute cases.
- Latanoprost demonstrated greater IOP reduction compared to timolol; disease progression observed over 5 years.
Conclusions:
- Primary angle closure disease is prevalent in India.
- Effective management is achievable with iridotomy and appropriate intraocular pressure control.
Aim:
To provide a synopsis of primary angle closure disease in India, and Indian studies on the same.
Results:
Primary angle closure glaucoma forms almost half of all adult primary glaucomas seen in a hospital setting in India. Anatomically, corneal diameters and anterior chamber depths were least in acute and chronic PACG eyes as compared to subacute eyes and controls. Besides relative pupillary block, a Valsalva maneuver during activities of daily living may be responsible for intermittent angle closure and raised IOP in predisposed eyes. Iridotomy alone, controlled the intraocular pressure in 66.7% of subacute eyes and 12.9% of the acute. Medical therapy was additionally required for 35.5% of the acute eyes, 12.1% of the subacute and 30.0% of the chronic cases. There was a greater mean and peak IOP reduction, achieved with 0.005% latanoprost once daily, 8.2 ± 2.0 mm Hg, compared with 0.5% timolol twice daily, 6.1 ± 1.7 mm Hg2. A progression of PACS to PAC was seen in 22%, PAC to PAC OHT in 38.7% and PAC OHT to PACG in 30.7% over 5 years.
Conclusions:
Primary angle closure disease is common in India, and can be managed well with iridotomy, followed by an appropriate control of IOP.
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