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Preventive effect of ginger (Zingiber officinale) pretreatment on renal ischemia-reperfusion in rats
1Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, I.R. Iran.
Background/Aims:
The present study examined the preventive effect of ginger against renal ischemia-reperfusion (I-R) injury.
Methods:
30 adult male rats were used. The animals were allocated to five groups of 6 rats: (1) normal (N), (2) normal + ginger (N+G), (3) right nephrectomy (Sham), (4) I-R, and (5) I-R + ginger (I-R+G). To induce renal ischemia, animals were unilaterally nephrectomized and subjected to 45 min of left renal pedicle occlusion with 24 h reperfusion. Ginger was administered orally 24 h and just before ischemia. At the end of the experiment, blood samples and urine were collected. The following renal functional parameters were studied: serum and urinary levels of creatinine and urea, fractional excretion of sodium, and creatinine clearance. Histopathological examination of the kidney was also performed.
Results:
Rats with renal I-R showed a significant increase in creatinine and urea concentration in serum and also a significant decrease in creatinine clearance compared with the other groups. In addition, renal histopathology in the I-R group showed severe alterations such as tubular dilatation and tubular epithelial necrosis. However, these changes were significantly reduced in the I-R+G group.
Conclusion:
This study suggests that ginger is a useful agent for the prevention of renal ischemia reperfusion-induced injury.
