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Updated: Jun 6, 2026

Isolating Interaction-Null/Impaired Mutants Using the Yeast Two-Hybrid Assay
Published on: December 29, 2023
The meaning of interaction
Xuefeng Wang1, Robert C Elston, Xiaofeng Zhu
1Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106-7281, USA.
Abstract:
Although recent studies have attempted to dispel the confusion that exists in regard to the definition, analysis and interpretation of interaction in genetics, there still remain aspects that are poorly understood by non-statisticians. After a brief discussion of the definition of gene-gene interaction, the main part of this study addresses the fundamental meaning of statistical interaction and its relationship to measurement scale, disproportionate sample sizes in the cells of a two-way table and gametic phase disequilibrium.
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