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Related Concept Videos

Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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Autophagy01:27

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Related Experiment Video

Updated: Jun 6, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

Selective autophagy and viruses.

Rhea Sumpter1, Beth Levine

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX USA.

Autophagy
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Selective autophagy clears cellular waste. This study reveals p62 targets Sindbis virus capsid for degradation, suggesting a role for selective autophagy in antiviral defense and disease.

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Purification of High Yield Extracellular Vesicle Preparations Away from Virus
07:15

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Published on: September 12, 2019

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Last Updated: Jun 6, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

Purification of High Yield Extracellular Vesicle Preparations Away from Virus
07:15

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Published on: September 12, 2019

Area of Science:

  • Cellular Biology
  • Virology
  • Immunology

Background:

  • Selective autophagy is crucial for clearing damaged organelles and pathogens.
  • The role of selective autophagy in viral clearance has been largely unexplored.
  • Viruses are common intracellular threats requiring efficient host defense mechanisms.

Purpose of the Study:

  • To investigate the role of selective autophagy in the context of viral infections.
  • To elucidate the mechanism by which viruses are targeted for autophagic degradation.
  • To explore the implications of selective viral autophagy in host immunity and pathogenesis.

Main Methods:

  • Utilized mouse models of Sindbis virus central nervous system (CNS) infection.
  • Performed in vitro experiments to study protein interactions and degradation pathways.
  • Assessed viral capsid clearance, p62 accumulation, and neuronal cell death.

Main Results:

  • Neuronal Atg5 deficiency impaired Sindbis virus capsid clearance in vivo.
  • p62 was found to interact with the Sindbis capsid protein.
  • p62 mediated the targeting of Sindbis capsid for degradation via autophagosomes.

Conclusions:

  • Selective autophagy, mediated by p62, plays a role in clearing Sindbis virus components.
  • This process may be critical for host defense against viral infections.
  • Dysregulation of selective viral autophagy could impact viral pathogenesis and host immunity.