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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
Published on: December 19, 2020
Searching for the holy grail of a staphylococcal vaccine
Isaac Thomsen1, Hannah Dudney, C Buddy Creech
1Department of Pediatrics, Division of Pediatric Infectious Diseases and Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine and Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
Abstract:
The pursuit of an effective staphylococcal vaccine has never been more critical, as community-associated MRSA has become the most common bacterial infection in the US. In this commentary, we will highlight new discoveries in the host response to colonization and infection with S. aureus, discuss potential antigens that might be used as vaccines, and make recommendations as to how the field can move forward towards discovering the "holy grail" of an effective staphylococcal vaccine.
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