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Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal

Mikhail V Blagosklonny1

  • 1Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA. blagosklonny@oncotarget.com

Cell Cycle (Georgetown, Tex.)
|December 15, 2010
PubMed

Insights

Pharmacologic suppression of aging is now possible using existing drugs that target sensing-signaling pathways like the mTOR pathway. This approach could extend healthy lifespan and prevent age-related diseases.

Area of Science:

  • Gerontology and pharmacology
  • Cellular signaling pathways
  • Drug discovery for aging

Background:

  • Aging is driven by sensing-signaling pathways, notably the mTOR pathway.
  • Clinically approved drugs targeting the mTOR pathway are available.
  • There is a significant opportunity to suppress aging and prevent diseases concurrently.

Purpose of the Study:

  • To propose a strategy for the pharmacologic suppression of aging.
  • To leverage existing drugs for extending healthy lifespan.
  • To address key questions in gerontology through drug intervention.

Main Methods:

  • Retrospective clinical studies
  • Animal and cellular models
  • Drug screening for efficacy and safety
  • Development of drug schedules and combinations

Main Results:

  • The study outlines a proposal for aging suppression, not empirical results.
  • Identifies potential for non-toxic, effective aging interventions.
  • Suggests a path towards extending healthy human lifespan.

Conclusions:

  • Pharmacologic suppression of aging is feasible with current medications.
  • Targeting sensing-signaling pathways offers a dual benefit for aging and disease.
  • Further research can lead to interventions for extending healthy life within our lifetime.

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