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Updated: Jun 6, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Novel functions of B cells in transplantation
Jeffrey L Platt1, Shoichiro Tsuji, Marilia Cascalho
1Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
Purpose Of Review:
This manuscript reviews current knowledge and recent findings regarding antibody-independent functions of B cells in transplantation.
Recent Findings:
Until recently the functions of B cells in transplantation have been attributed almost entirely to the antibodies they produce. However, the results of recent trials of B-cell-depleting agents for treatment of antibody-mediated rejection as well as auto-immune disease raised awareness that B cells mediate functions independent of antibody synthesis.
Summary:
These 'nonclassical' functions place B cells at the center of immune regulation with the power to enhance or inhibit immunity.
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