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Related Experiment Video

Updated: Jun 6, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Stem cell-derived islet cells for transplantation.

Juan Domínguez-Bendala¹, Luca Inverardi, Camillo Ricordi

¹Diabetes Research Institute, University of Miami Leonard M. Miller School of Medicine, Department of Surgery, Miami, FL 33136, USA.

Current Opinion in Organ Transplantation

|December 15, 2010

Summary

Stem cell therapies show promise for type 1 diabetes treatment, offering new sources of insulin-producing cells. Advances include human embryonic stem cell differentiation and direct reprogramming, paving the way for future clinical applications.

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Last Updated: Jun 6, 2026

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Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Published on: June 23, 2023

Area of Science:

Regenerative Medicine
Endocrinology
Stem Cell Biology

Background:

Type 1 diabetes (T1D) treatment relies on replacing lost insulin-producing beta cells.
Islet transplantation is limited by the scarcity of suitable donor cells.
Stem cell-based strategies offer a potential renewable cell source for T1D therapy.

Purpose of the Study:

To review recent advancements in stem cell-based approaches for T1D.
To highlight progress in differentiating stem cells into insulin-producing beta cells.
To discuss direct reprogramming of somatic cells into functional beta cells.

Main Methods:

Review of recent scientific literature on stem cell differentiation and reprogramming for T1D.
Analysis of progress in human embryonic stem (hES) cell differentiation protocols.
Evaluation of direct reprogramming techniques from non-endocrine tissues.

Main Results:

Human embryonic stem cells show promise for clinical trials due to successful differentiation methods.
Adult stem cell differentiation lacks a gold standard, requiring further research and consensus.
Direct reprogramming presents a potential alternative strategy for restoring pancreatic endocrine function.

Conclusions:

Strategic decisions are crucial to optimize the therapeutic potential of each stem cell approach.
Human embryonic stem cells are nearing clinical application for T1D.
Further research is needed to establish robust protocols for adult stem cell differentiation and reprogramming.