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Related Concept Videos

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Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...
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Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
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Endoscopic Procedures II: Colonoscopy

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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

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Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
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Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
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Multifunctional carbon-nanotube cellular endoscopes.

Riju Singhal1, Zulfiya Orynbayeva, Ramalingam Venkat Kalyana Sundaram

  • 1Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.

Nature Nanotechnology
|December 15, 2010
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Researchers developed a carbon-nanotube endoscope for minimally invasive cell interrogation and fluid transport. This novel device enables precise intracellular diagnostics and targeted delivery at the single organelle level.

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Area of Science:

  • Nanotechnology
  • Cell Biology
  • Biomedical Engineering

Background:

  • Conventional cell interrogation tools like micropipettes and AFM tips have limitations.
  • Conical geometries can cause cell damage during penetration.
  • Existing devices often lack continuous fluid handling capabilities.

Purpose of the Study:

  • To develop a novel carbon-nanotube-based endoscope for intracellular analysis.
  • To enable continuous fluid handling and diagnostics at the single organelle level.
  • To overcome limitations of existing cell probing technologies.

Main Methods:

  • Fabrication of a carbon-nanotube endoscope by attaching a multiwalled carbon nanotube to a glass pipette.
  • Utilizing the endoscope for intracellular probing with high spatial resolution (~100 nm).
  • Incorporating magnetic nanoparticles for remote maneuverability and fluid transport.

Main Results:

  • The endoscope successfully probed the intracellular environment without disrupting the cell.
  • Achieved precise spatial resolution for organelle-level analysis.
  • Demonstrated remote transport of nanoparticles and attoliter fluid volumes.

Conclusions:

  • The carbon-nanotube endoscope offers a versatile platform for minimally invasive intracellular research.
  • Potential applications include targeted drug delivery and single-cell surgery.
  • Integration with standard laboratory instruments facilitates broad adoption.