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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.

Yelena Koldobskaya1, Erica M Duguid, David M Shechner

  • 1Department of Chemistry, University of Chicago, Chicago, Illinois, USA.

Nature Structural & Molecular Biology
|December 15, 2010
PubMed
Summary

Antibody fragments (Fabs) act as novel RNA crystallization chaperones, aiding structure determination. This new system targets a portable RNA epitope, offering advantages over existing methods for RNA structure analysis.

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