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Updated: Jun 6, 2026

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
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Placental vascular obstructive lesions: risk factor for developing necrotizing enterocolitis.

Laure Dix1, Matthias Roth-Kleiner, Maria-Chiara Osterheld

  • 1Institute of Pathology, University of Lausanne, CH-1011 Lausanne, Switzerland.

Pathology Research International
|December 15, 2010
PubMed
Summary

Fetal vascular obstructive lesions in placentae are strongly associated with necrotizing enterocolitis (NEC) in premature infants. This finding suggests these placental lesions may be a significant risk factor for developing NEC.

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Published on: November 30, 2021

Area of Science:

  • Neonatal Medicine
  • Perinatal Pathology
  • Obstetrics

Background:

  • Necrotizing enterocolitis (NEC) is a severe neonatal disease primarily affecting preterm infants.
  • The precise pathogenesis of NEC remains largely unknown.
  • Understanding risk factors is crucial for preventing NEC.

Purpose of the Study:

  • To investigate the association between fetal vascular obstructive lesions in placentae and the development of NEC in preterm infants.
  • To compare placental findings between NEC patients and a control group.
  • To analyze findings specifically in infants under 30 weeks gestation.

Main Methods:

  • Comparative analysis of placental pathology.
  • Examination of placentae from preterm infants with and without NEC.
  • Stratification of analysis by gestational age (<30 weeks).

Main Results:

  • Fetal vascular obstructive lesions were found in 65% of placentae from NEC patients versus 17% in controls.
  • In infants <30 weeks gestation, lesions were present in 58.5% of NEC placentae vs. 24.5% in controls.
  • A significant difference was observed between NEC and control groups.

Conclusions:

  • Fetal vascular obstructive lesions show a strong association with NEC in preterm infants.
  • These placental lesions are proposed as a potential risk factor for NEC development.
  • Further research is warranted to elucidate the causal link.