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Storage Stability Study of Salicylate-based Poly(anhydride-esters)
Brittany M Deronde1, Ashley L Carbone, Kathryn E Uhrich
1Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey, 08854-8087.
Polymer Degradation and Stability
|December 15, 2010
Summary
Biodegradable poly(anhydride-ester) polymers are best stored at low temperatures. Storing these hydrolytically labile polymers below 4°C preserves molecular weight and minimizes hydrolysis, ensuring material integrity over time.
Area of Science:
- Polymer Science
- Materials Science
- Biomaterials Engineering
Background:
- Biodegradable polymers are crucial for various applications, including drug delivery and tissue engineering.
- Poly(anhydride-esters) are a class of hydrolytically labile polymers with significant potential.
- Understanding their storage stability is essential for consistent performance and shelf-life.
Purpose of the Study:
- To evaluate the storage stability of a biodegradable salicylate-based poly(anhydride-ester).
- To determine the impact of various storage temperatures on polymer properties over time.
- To provide guidelines for optimal storage conditions for these hydrolytically degradable polymers.
Main Methods:
- Polymer samples were stored in powdered form at temperatures ranging from -12°C to 50°C.
- Samples were monitored over four weeks for changes in color, glass transition temperature, molecular weight, and hydrolysis.
- Analytical techniques were used to quantify the extent of hydrolysis and assess physical property changes.
Main Results:
- Samples stored at lower temperatures (-12°C, 4°C) showed minimal changes in molecular weight and hydrolysis.
- Samples stored at higher temperatures (27°C, 37°C, 50°C) exhibited significant hydrolysis and degradation.
- Elevated temperatures led to noticeable changes in polymer color and glass transition temperature.
Conclusions:
- Storage temperature critically affects the stability of hydrolytically labile poly(anhydride-esters).
- Low-temperature storage (below 4°C) is recommended to maintain polymer integrity.
- Storing under an inert atmosphere is also advised to further enhance stability and prevent degradation.
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