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Topiramate for hyperphagia associated with a third ventricle mass.

Alejandra Postlethwaite¹, Bernardo Ng

¹Dr. Postlethwaite is from the Harvard South Shore Psychiatry Residency Training Program, Harvard Medical School, Adult Psychiatry Resident, Boston, Massachusetts.

Psychiatry (Edgmont (Pa. : Township))

|December 15, 2010

Summary

A third ventricle mass caused eating disorders, agitation, and cognitive issues. Topiramate effectively treated hyperphagia and agitation, offering a potential therapeutic avenue for hypothalamic dysfunction.

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Area of Science:

Neuroendocrinology
Neurology
Pharmacology

Background:

Hypothalamic regulation of eating is crucial for homeostasis.
Physiopathologic events can disrupt hypothalamic functions, leading to eating disorders.
Third ventricle masses are rare but can impact adjacent neural structures.

Observation:

A case report details an individual with a third ventricle mass.
The patient exhibited neuropsychiatric symptoms including hyperphagia, agitation, and cognitive impairment.
These symptoms suggest a disruption of hypothalamic control over appetite and behavior.

Findings:

Pharmacological intervention with topiramate demonstrated efficacy in managing hyperphagia and agitation.
Topiramate provided superior relief compared to other previously attempted agents.
The study explores potential mechanisms underlying topiramate's effectiveness in this context.

Implications:

Topiramate may be a valuable therapeutic option for managing hyperphagia and agitation associated with hypothalamic lesions.
Understanding the neurobiological underpinnings of such conditions can guide future treatment strategies.
This case highlights the importance of considering neurological causes for complex eating and behavioral disturbances.