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IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells

Barbara Salani1, Mario Passalacqua, Sara Maffioli

  • 1Department of Endocrinology and Medicine (DiSEM), University of Genova, Genova, Italy.

Plos One
|December 15, 2010
PubMed
Summary

Caveolae proteins Caveolin-1 and PTRF/Cavin are crucial for insulin-like growth factor-I receptor (IGF-IR) internalization. Modulating these proteins may offer new ways to control IGF-IR signaling pathways.

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