Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling Relationships among Pain and Function in Individuals with Knee Osteoarthritis in the A2CPS Cohort.

The Clinical journal of pain·2026
Same author

Appropriate translational designs for determining causal force-based (manual therapy) treatment mechanisms.

Musculoskeletal science & practice·2026
Same author

BINge: Multispecies Ortholog Clustering for Differential Gene Expression Analyses.

Molecular ecology resources·2026
Same author

Examining the individual-level impact of neighborhood-level violent crime on resident mental health.

Psychological trauma : theory, research, practice and policy·2026
Same author

Stakeholder Attitudes Toward the Implementation of School-Based, Universal, Mental Health Screening: Student, Caregiver, and Teacher Perspectives.

International journal of environmental research and public health·2025
Same author

Democratising high performance computing for bioinformatics through serverless cloud computing: A case study on CRISPR-Cas9 guide RNA design with Crackling Cloud.

PLoS computational biology·2025

Related Experiment Video

Updated: Jun 6, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Computational micromodel for epigenetic mechanisms.

Karthika Raghavan1, Heather J Ruskin, Dimitri Perrin

  • 1Centre for Scientific Computing and Complex Systems Modeling, Dublin City University, Dublin, Ireland. kaghavan@computing.dcu.ie

Plos One
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Environmental stress alters epigenetic patterns, impacting gene expression and potentially leading to cancer. This study models DNA methylation and histone modifications to understand their role in gene regulation.

More Related Videos

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Related Experiment Videos

Last Updated: Jun 6, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Area of Science:

  • Epigenetics and Molecular Biology
  • Computational Biology and Bioinformatics

Background:

  • Epigenetic modifications like DNA methylation and histone modifications are crucial for regulating gene expression.
  • Environmental stress can disrupt these epigenetic patterns, potentially leading to diseases such as cancer.

Purpose of the Study:

  • To computationally model the influence of histone modifications and DNA methylation on gene expression.
  • To investigate the interdependency between DNA methylation and histone modifications.
  • To characterize histone modifications in relation to specific DNA methylation levels.

Main Methods:

  • Utilizing a stochastic approach to model epigenetic interactions.
  • Analyzing the relationship between DNA methylation patterns and gene transcription.
  • Characterizing histone modifications under varying DNA methylation conditions.

Main Results:

  • Detailed characterization of histone modifications associated with specific DNA methylation levels.
  • Exploration of the intricate relationship between DNA methylation and gene transcription.
  • Insights into the dynamic interplay of epigenetic elements in gene regulation.

Conclusions:

  • The study provides a computational framework for understanding epigenetic regulation.
  • Findings highlight the link between environmental stress, epigenetic alterations, and disease initiation.
  • Further research into epigenetic mechanisms can inform disease prevention and treatment strategies.