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Updated: Jun 6, 2026

Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
Published on: August 25, 2022
[Overcoming of radiation resistances]
C Friesen1, I Hormann, M Roscher
1Institut für Rechtsmedizin, Universität Ulm, Prittwitzstr. 6, 89075 Ulm. claudia.friesen@uni-ulm.de
Abstract:
Despite good achievements in prevention and control, cancer is still a leading cause of death worldwide. The development of resistances against conventional treatment modalities is one of the main causes of failure in the treatment of cancer. Radio- and chemotherapies fail frequently due to intrinsic or acquired resistances in apoptotic signalling pathways or alterations in DNA-repair processes. Targeted radiotherapies employing α-particle-emitting radionuclides and Auger-emitting electrons are a promising approach in cancer treatment to break radio- and chemoresistance by overcoming DNA-repair mechanisms and reversing deficient activation of apoptotic pathways in cancer cells.
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