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Updated: Jun 6, 2026
11:39
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
Published on: June 9, 2019
[Metabolic micromilieu in tumours].
1Institut für Physiologie und Pathophysiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Duesbergweg 6, 55128 Mainz. mue-kli@uni-mainz.de
Nuklearmedizin. Nuclear Medicine
|December 15, 2010
Summary
High lactate levels in solid malignant tumors correlate with increased malignancy and poorer patient survival. These high lactate tumors also exhibit greater resistance to radiation therapy, indicating a significant therapeutic challenge.
Area of Science:
- Oncology
- Cancer Metabolism
- Biochemistry
Context:
- Solid malignant tumors exhibit a heterogeneous metabolic microenvironment.
- Key hallmarks include hypoxia, tissue acidosis, and abnormal microcirculation.
- Tumor glycolysis and lactate accumulation are areas of intense research.
Purpose:
- To investigate the spectrum of lactate accumulation across various tumor types.
- To determine the relationship between lactate levels, metastasis, and patient survival.
- To explore the correlation between tumor lactate content and radio-resistance.
Summary:
- Tumors show a wide range of lactate accumulation, with metastatic lesions having significantly higher levels than non-metastatic ones.
- Patients with high-lactate tumors demonstrate significantly worse survival outcomes compared to those with low-lactate tumors.
- A positive correlation exists between tumor lactate content and resistance to radiation therapy.
Impact:
- High-lactate tumors are associated with increased malignancy.
- Elevated lactate levels indicate greater therapeutic resistance, particularly to radiation.
- Lactate levels may serve as a prognostic biomarker for patient outcomes and treatment response.
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