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Updated: Jun 6, 2026

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

Dermatophytes: host-pathogen interaction and antifungal resistance.

Nalu Teixera de Aguiar Peres¹, Fernanda Cristina Albuquerque Maranhão, Antonio Rossi

¹Universidade de São Paulo, SP, Brazil.

Anais Brasileiros De Dermatologia

|December 15, 2010

Summary

Dermatophyte infections, a public health concern, involve complex interactions where fungi adapt metabolically to infect hosts. Understanding these fungal-host interactions and antifungal resistance mechanisms is key to developing new therapies.

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Last Updated: Jun 6, 2026

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

Area of Science:

Medical Mycology
Infectious Diseases
Molecular Biology

Background:

Cutaneous mycoses are common human infections with public health implications, especially for immunocompromised individuals.
Dermatophytes cause infections by adapting their metabolism to adhere to, penetrate, and survive within host tissues.
Host immune responses are activated through intracellular signaling pathways in response to fungal stimuli.

Purpose of the Study:

To review the biology of dermatophytes.
To emphasize dermatophyte-host interactions.
To explore mechanisms of antifungal resistance.

Main Methods:

Literature review of dermatophyte-host interactions.
Analysis of metabolic adaptations in dermatophytes.
Examination of host immune responses to fungal pathogens.
Review of established and emerging antifungal resistance mechanisms.

Main Results:

Dermatophyte infections involve pathogen metabolic adaptations for host tissue invasion and nutrient acquisition.
Fungal metabolism, morphogenesis, and stress responses are interconnected.
Host cells activate signaling pathways to mount an immune response against dermatophytes.
Understanding these molecular interactions is crucial for developing novel therapeutic strategies.

Conclusions:

Comprehending the molecular basis of dermatophyte-host interactions and antifungal resistance is vital.
This knowledge can inform the development of new treatments for cutaneous mycoses.
Targeting fungal metabolic pathways and resistance mechanisms offers potential therapeutic avenues.