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Related Experiment Video

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Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

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Periumbilical and periareolar perforating pseudoxanthoma elasticum.

Aline Lopes Bressan¹, Bárbara Nader Vasconcelos, Roberto Souto da Silva

¹Hospital Universitário Pedro Ernesto, Rio de Janeiro, RJ, Brasil.

Anais Brasileiros De Dermatologia

|December 15, 2010

Summary

Periumbilical perforating pseudoxanthoma elasticum is a rare skin condition linked to altered elastic fibers, possibly from trauma. Histopathology confirmed calcium deposits and degraded elastic fibers in a 70-year-old woman.

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Area of Science:

Dermatology
Pathology
Medical Research

Background:

Periumbilical perforating pseudoxanthoma elasticum (PXE), also known as perforating calcific elastosis, is a rare skin disorder.
Its pathogenesis is hypothesized to involve alterations in dermal elastic fibers, potentially triggered by trauma.

Observation:

A case study of a 70-year-old woman presenting with long-standing periareolar and periumbilical lesions.
Clinical manifestations included blackish macules and keratotic surface papules.

Findings:

Histopathological examination revealed significant alterations in elastic fibers.
These fibers were replete with calcium deposits, and a path within the dermis showed degraded elastic fibers internally.
These findings confirmed the clinical diagnosis of periumbilical perforating pseudoxanthoma elasticum.

Implications:

This case highlights the characteristic histopathological features of periumbilical perforating pseudoxanthoma elasticum.
Understanding the role of elastic fiber degeneration and calcification is crucial for diagnosing and potentially managing this rare condition.