Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
What is the Immune System?01:38

What is the Immune System?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case for diagnosis.

Anais brasileiros de dermatologia·2014
Same author

Primary essential cutis verticis gyrata - case report.

Anais brasileiros de dermatologia·2014
Same author

Linear IgA bullous dermatosis: report of an exuberant case.

Anais brasileiros de dermatologia·2013
Same author

The importance of trichological examination in the diagnosis of alopecia areata.

Anais brasileiros de dermatologia·2011
Same author

Bullous pemphigoid in younger adults: three case reports.

Anais brasileiros de dermatologia·2011
Same author

[Case for diagnosis].

Anais brasileiros de dermatologia·2010
Same journal

Correlation between invasion front and survival of patients with cutaneous melanomas.

Anais brasileiros de dermatologia·2026
Same journal

Nanocarriers for topical minoxidil in androgenetic alopecia: systematic review of preclinical and clinical evidence.

Anais brasileiros de dermatologia·2026
Same journal

Pediatric psoriasis: from immunogenetics to targeted therapies.

Anais brasileiros de dermatologia·2026
Same journal

Perifollicular fibrosis and inflammation in androgenetic alopecia and seborrheic dermatitis: diagnostic challenges in differentiation from fibrosing alopecia in a pattern distribution.

Anais brasileiros de dermatologia·2026
Same journal

Exuberant cutaneous lymphoepithelioma-like carcinoma: clinicopathological correlation in an aggressive case<sup>⋆</sup>.

Anais brasileiros de dermatologia·2026
Same journal

Tumor-like periungual cutaneous sporotrichosis in an endemic area.

Anais brasileiros de dermatologia·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Immunopathogenesis of psoriasis.

Ana Paula Galli Sanchez1

  • 1University of Sao Paulo, SP, Brazil. apc-med@hotmail.com

Anais Brasileiros De Dermatologia
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Psoriasis, a common inflammatory skin disease affecting 1% of Brazilians, involves Th17 and Th1 cells. This article explores the interplay between innate immunity cells like dendritic cells and keratinocytes, and adaptive immunity T lymphocytes in its development.

Related Experiment Videos

Last Updated: Jun 6, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Area of Science:

  • Immunology
  • Dermatology
  • Inflammatory Diseases

Background:

  • Psoriasis is a prevalent inflammatory skin condition impacting 1% of the Brazilian population.
  • The pathogenesis of psoriasis is understood to involve specific T helper cell subsets, namely Th17 and Th1 cells.
  • Understanding the immune mechanisms underlying psoriasis is crucial for developing effective treatments.

Purpose of the Study:

  • To discuss the complex interactions between innate and adaptive immune components in psoriasis pathogenesis.
  • To highlight the roles of dendritic cells and keratinocytes in initiating and perpetuating the inflammatory response.
  • To elucidate the contribution of T lymphocytes to the immunopathogenesis of this common skin disease.

Main Methods:

  • Review of current literature on psoriasis immunology.
  • Analysis of the roles of innate immune cells (dendritic cells, keratinocytes).
  • Examination of adaptive immune cell involvement (T lymphocytes, Th17, Th1 cells).

Main Results:

  • The article details the critical involvement of Th17 and Th1 cells in psoriasis.
  • It elaborates on the interplay between innate immunity (dendritic cells, keratinocytes) and adaptive immunity (T lymphocytes).
  • The discussion emphasizes how these interactions drive the inflammatory processes characteristic of psoriasis.

Conclusions:

  • The pathogenesis of psoriasis is a result of intricate crosstalk between innate and adaptive immune systems.
  • Dendritic cells and keratinocytes play key roles in activating T lymphocytes, perpetuating the disease.
  • Further research into these interactions may reveal novel therapeutic targets for psoriasis management.