Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Social Anxiety Disorder01:28

Social Anxiety Disorder

Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mpox in a patient with AIDS: clinical management with tecovirimat and surgical correction of unaesthetic scars.

Anais brasileiros de dermatologia·2025
Same author

Lobomycosis: single lesion on the lip.

Anais brasileiros de dermatologia·2024
Same author

Hidradenocarcinoma.

Anais brasileiros de dermatologia·2021
Same author

Atypical manifestations of recent syphilis: study of 19 cases.

Anais brasileiros de dermatologia·2020
Same author

Osteonevus of Nanta: a case report in a combined melanocytic nevus.

Anais brasileiros de dermatologia·2020
Same author

Superficial acral fibromyxoma.

Anais brasileiros de dermatologia·2017

Related Experiment Video

Updated: Jun 6, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

Do you know this syndrome?

Priscilla Maria Rodrigues Pereira1, Carlos Alberto Chirano Rodrigues, Livia Lima de Lima

  • 1Hospital Universitário Getúlio Vargas, Universidade Federal do Amazonas, Manaus, AM, Brasil.

Anais Brasileiros De Dermatologia
|December 15, 2010
PubMed
Summary

Laugier-Hunziker syndrome presents as acquired oral and genital mucosal hyperpigmentation, often with nail pigmentation. This case highlights key clinical signs and typical histopathology for this rare, benign condition.

Related Experiment Videos

Last Updated: Jun 6, 2026

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

Area of Science:

  • Dermatology
  • Oral Medicine
  • Pathology

Background:

  • Laugier-Hunziker syndrome is a rare condition characterized by hyperpigmentation of mucosal surfaces and nails.
  • It is an acquired disorder with an unknown etiology.
  • The syndrome requires careful differential diagnosis due to its variable presentation.

Observation:

  • This case report details a patient with longitudinal melanonychia on fingernails and toenails.
  • The patient also presented with Hutchinson's sign and lenticular pigmentation of the lips and oral mucosa.
  • Clinical and histopathological findings were consistent with Laugier-Hunziker syndrome.

Findings:

  • Histopathological analysis confirmed the diagnosis, showing typical features of melanocytic hyperplasia.
  • The differential diagnosis was broad, necessitating thorough evaluation.
  • Laugier-Hunziker syndrome is a benign entity.

Implications:

  • This case underscores the importance of considering Laugier-Hunziker syndrome in the differential diagnosis of mucocutaneous hyperpigmentation.
  • Early recognition can prevent unnecessary investigations and anxiety for patients.
  • Understanding the typical presentation aids in accurate diagnosis and management.