Related Experiment Video
Updated: Jun 6, 2026

11:30
Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
Published on: July 25, 2025
[Keel-based lumbar total disk replacement: Prodisc-L and Prodisc-O].
Michael Ogon1, Alexander Tuschel
1Orthopädische Abteilung III, Wirbelsäulenchirurgie, Orthopädisches Spital Speising, Wien, Österreich. michael.ogon@oss.at
Operative Orthopadie Und Traumatologie
|December 15, 2010
Summary
This study shows that Prodisc-L artificial disc replacement significantly improves chronic low back pain and function for patients with degenerative disc disease. Patients experienced substantial reductions in pain and disability after the procedure.
Area of Science:
- Spine surgery
- Orthopedic surgery
- Biomedical engineering
Context:
- Chronic low back pain due to degenerative disc disease often proves resistant to conservative treatments.
- Degenerative disc disease can lead to significant pain, disability, and reduced quality of life.
- Maintaining motion in the treated spinal segment is crucial for long-term outcomes and preventing adjacent segment degeneration.
Purpose:
- To evaluate the efficacy of Prodisc-L artificial lumbar disc replacement in patients with chronic low back pain.
- To assess the improvement in pain, function, and quality of life following lumbar disc arthroplasty.
- To determine the impact of Prodisc-L implantation on maintaining spinal segment motion and reducing adjacent segment degeneration.
Summary:
- Eighty-seven Prodisc-L prostheses were implanted in 71 patients with degenerative disc disease.
- Clinical outcomes were assessed using the Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and SF-36 questionnaire.
- At 2-year follow-up, significant improvements were observed: VAS decreased from 7.5 to 3.5, ODI from 46.0 to 22.9, and SF-36 Physical Component Summary Score increased from 30.5 to 44.8.
Impact:
- Prodisc-L implantation offers a viable surgical option for managing chronic low back pain associated with degenerative disc disease.
- The procedure leads to significant and sustained improvements in pain reduction and functional capacity.
- Maintaining motion at the treated level may help prevent further degeneration in adjacent spinal segments.
Related Concept Videos
Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...