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Related Concept Videos

Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.

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Related Experiment Video

Updated: Jun 6, 2026

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

[Keel-implants: Activ-L].

Karsten Wiechert1

  • 1Abteilung für Wirbelsäulenchirurgie, Hessingpark-Clinic, Augsburg, Germany. karsten.wiechert@hessingpark-clinic.de

Operative Orthopadie Und Traumatologie
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

The Activ-L total disc replacement offers flexible anchoring and preserves spinal mobility for low-back pain relief. Early results show comparable outcomes to existing devices with potentially lower wear.

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Area of Science:

  • Spinal surgery
  • Biomaterials
  • Orthopedic devices

Context:

  • Lumbar disc degeneration causes refractory low-back pain.
  • Total disc replacement aims to relieve pain and restore motion.
  • The Activ-L device offers a modular design with flexible anchoring options.

Purpose:

  • To evaluate the early clinical outcomes of the Activ-L total disc replacement.
  • To assess the device's efficacy in restoring segmental mobility and providing pain relief.
  • To compare the Activ-L device with established disc replacement systems.

Summary:

  • The Activ-L total disc replacement features a modular design with spike or keel anchoring and a semiconstrained UHMWPE inlay.
  • A standardized, minimally invasive anterior surgical technique is employed.
  • Early clinical results are comparable to existing devices, with significantly lower particle wear observed for the inlay.

Impact:

  • Provides a viable treatment option for lumbar disc degeneration.
  • Demonstrates potential for improved longevity due to reduced inlay wear.
  • Contributes to the field of motion-preserving spinal surgery.